新澳门六合彩内幕信息

新澳门六合彩内幕信息

Health News

Dr. Juan Sanchez-Ramos has dedicated his career to seeking a cure for Huntington鈥檚 disease

photo of jsr

Juan Sanchez-Ramos, MD, PhD, has dedicated much of his career to learning everything he can about Huntington鈥檚 disease, a rare hereditary neurodegenerative illness that impacts cognition, mood and movement. 

His work has filled the medical literature with findings that offer a better understanding of how the disease begins, progresses, and is passed on to progeny. His work has led to a more practical method for delivery of gene therapy via a nose-to-brain instillation of nanoparticles. This approach is safe,  non-invasive and does not need neurosurgical intervention. 

This month, Dr. Sanchez-Ramos is retiring from 新澳门六合彩内幕信息Health, leaving a legacy of valuable work and a story for others to know 鈥 that the path into and across a career is not always a straight line.

He has been with 新澳门六合彩内幕信息Health since 1996.

Dr. Sanchez-Ramos is the Helen Ellis Professor of Neurology and director of the HDSA Huntington鈥檚 Disease Center of Excellence in the 新澳门六合彩内幕信息Health Morsani College of Medicine. He is a prominent figure in neurodegenerative disease research and patient care, especially in Huntington鈥檚 disease, an inherited brain disorder that leads to a gradual decline in movement, mood, and cognitive functions.  

The 新澳门六合彩内幕信息Health Huntington鈥檚 Disease Center of Excellence, established in 2006 and supportd by the HD Society of America, has been instrumental in advancing gene therapies for Huntington鈥檚 disease and has been a transformative resource for its patient鈥檚 lives.  

byrd2024

The 新澳门六合彩内幕信息Health Huntington鈥檚 Disease Center of Excellence & 新澳门六合彩内幕信息Health Byrd Alzheimer鈥檚 Center and Research Institute.

 
At the start of Dr. Sanchez-Ramos's career, he was Initially drawn to medicine by his father鈥檚 influence. However, he found himself equally captivated by the world of art during his undergraduate years at the University of Chicago while studying pre-medicine. After receiving his bachelor's degree, Dr. Sanchez-Ramos made a bold decision 鈥 to drop out of school and pursue a career as an artist.  
 
He embarked on a 3 year artistic journey in Paris, where he initially planned to study at the Ecole des Beaux Arts. He never did enroll in the Academy and worked as a free-lance artist in Paris, Malaga and Copenhagen. He finally realized the life of an artist is very difficult, and he redirected his career to the study of Neurosciences and Medicine.  While attending graduate school at the university, he pursued graduate studies in neuropharmacology and ended up doing his PhD on the mechanisms of opioid tolerance, dependence, and withdrawal. 

  • Many of these drawing and "inklings" date back to early years as Graphics Editor of Chicago Review. 

  • Many of these drawing and "inklings" date back to early years as Graphics Editor of Chicago Review. 

  • Many of these drawing and "inklings" date back to early years as Graphics Editor of Chicago Review. 


 
A paper came out that uncovered an opioid analog made in an underground lab was producing symptoms of Parkinson鈥檚 through IV opioid abuse. This sparked Dr. Sanchez-Ramos's interest because it provided a link between his basic research on opioids and its potential cause of neurological diseases like Parkinson's. This inspired him to go to medical school at the University of Illinois in Chicago. In this transition from his basic research to medical school, he followed up with a neurology residency and a fellowship in movement disorders.  
 
Decades later he was invited by Nancy Wexler, a renowned geneticist, to be involved in the Huntington鈥檚 Disease Research project. The research gathered led to a significant breakthrough 鈥 the discovery in 1992 of the Huntington鈥檚 disease gene.  
 
Soon after, Dr. Sanchez-Ramos was recruited to the USF, where he would establish a cutting-edge lab and clinic and hold the Helen Ellis Endowed Chair. Initially, it was focused on Parkinson鈥檚 disease but later it expanded to Huntington鈥檚 Disease.  
Through multidisciplinary collaboration, Huntington鈥檚 Disease Center of Excellence at 新澳门六合彩内幕信息Health provides comprehensive care for patients, recognizing the complex array of symptoms that accompany these devastating neurological disorders. By 2006, it had annual grants from the Huntington's Disease Society of America in New York to operate as a center of excellence. 

鈥淭his was an incredible blessing to all these patients and their families to have this in place... But in addition to that, it has created a cohort of patients that we have been able to follow, study, and test new gene therapy treatments of Huntington鈥檚 disease that have the potential to treat or cure the disease.鈥 Dr. Clifton Gooch MD, professor and chair of the 新澳门六合彩内幕信息Health Morsani College of Medicine鈥檚 Department of Neurology, 
 

nanoparticle research

Image showing nanoparticle delivery system findings.



While at 新澳门六合彩内幕信息Health, Dr. Sanchez-Ramos and his team developed a nanoparticle system that could be loaded with gene modifying molecules and could be delivered intranasally to combat the progression of Huntington鈥檚 disease. This was partially funded by the National Institute of Neurological Disorders and Stroke in the NIH. Dr. Sanchez-Ramos and colleagues continue to seek funding to pursue this gene therapy treatment even further. 
 
鈥淭he goal is to prevent this from happening,鈥 Dr. Sanchez-Ramos said. 鈥淲e already can identify those individuals who carry the genetic mutation. We know the earlier that we can start treatment the less likely the person will develop the illness. So, if we identify a person who has the mutated gene and we can give therapy that prevents the expression of the mutant gene, that would a great accomplishment, in essence, a cure for Huntington鈥檚 disease.鈥  
 
鈥淗e's the one who completely set this up from the very beginning,鈥 Dr. Gooch said. 鈥淭he clinic has helped hundreds of families and patients. In addition to playing a role in helping push this work forward... I think the work that Juan and others have done is going to lead us to a cure for Huntington鈥檚 disease.鈥 

Photos, video, and story by Ryan Rossy, 新澳门六合彩内幕信息Health Communications

Return to article listing

About Health News

新澳门六合彩内幕信息Health News highlights the great work of the faculty, staff and students across the four health colleges – Morsani College of Medicine, College of Public Health, College of Nursing and Taneja College of Pharmacy – and the multispecialty physicians group. 新澳门六合彩内幕信息Health, an integral part of the 新澳门六合彩内幕信息, integrates research, education and health care to reach our shared value - making life better.